Disposition of disodium cromoglycate administered in three particle sizes.
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چکیده
منابع مشابه
Actions of salbutamol, disodium cromoglycate, and placebo administered as aerosols in acute asthma.
The effects on the peak expiratory flow rate of the drug sequences, placebo-salbutamol-disodium cromoglycate and placebo-disodium cromoglycate-salbutamol administered via a nebuliser were examined in 35 children with asthma. Twenty children were each examined once within 4 hours of admission to hospital with an acute attack of asthma, and the remaining 15 children were examined later in the att...
متن کاملX-ray analysis of disodium cromoglycate.
Disodium cromoglycate (I; DSCG) was introduced in 1968 for the treatment of bronchial asthma. Evidence concerning its principal effects and possible mode of action has been described at some length in the recent literature (Cox, 1971 ; Cox & Altoanyan, 1970). Crystals of the compound exhibit a remarkable reversible water absorption (Cox, Woodard & McCrone, 1971), the number of water molecules p...
متن کاملDisodium cromoglycate in the treatment of chronic proctitis.
The effect of topical disodium cromoglycate (DSCG) has been examined in 30 patients with chronic active proctitis using a double-blind crossover trial. Each treatment period was four weeks and patients were given DSCG 200 mg by enema twice daily and 100 mg orally three times each day. Twenty-six patients completed the trial successfully, 14 responded to DSCG treatment, two improved with placebo...
متن کاملColumnar molecular aggregation in the aqueous solutions of disodium cromoglycate.
Stack, chimneylike, and threadlike assemblies have previously been proposed for the structure of disodium cromoglycate (DSCG) aggregates in aqueous solutions. The results of the synchrotron x-ray scattering investigations reported here reveal the formation of simple columnar assemblies with π-π stacking at a separation of 3.4 Å between the DSCG molecules. Lateral separation between the assembli...
متن کاملDisodium cromoglycate in the prevention of induced asthma.
In 13 patients with allergic asthma disodium cromoglycate protected fully only two from an allergen-induced asthmatic attack.Inhalation of disodium cromoglycate did not improve lung function in five patients with long-standing chronic asthma.Previous clinical trials do not show convincing evidence that this drug improves bronchial asthma in a high percentage of cases, but it seems to help a sma...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1975
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1975.tb01586.x